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Front Neurosci 10:197722 Sang Z, Wang K, Dong J, Tang L (2022) Alzheimers disease: updated multi-targets therapeutics are in clinical and in progress

Peptides Legal status: Not FDA-approved for human use (except specific GLP-1s) Sold as "research chemicals" Legal to buy and possess in most countries Not scheduled controlled substances Gray area but generally tolerated Availability: Widely available online from peptide vendors Quality varies significantly between sources Third-party testing available from reputable vendors Requires reconstitution from powder form Sport legality: Banned by most athletic organizations (WADA) Difficult to detect (short half-lives) Detection windows typically 24-48 hours Many athletes use despite bans SARMs Legal status: Not FDA-approved for human use Technically illegal to sell for human consumption Sold as "research chemicals" or "not for human use" FDA has issued warning letters to SARM vendors Some countries have scheduled them as controlled substances Availability: Available online but legal situation more precarious Quality control major concern (many products contaminated) Mislabeling common (tested products often don't match labels) Generally comes as capsules or liquid Sport legality: Banned by all major athletic organizations Easier to detect than peptides (longer half-lives) Detection windows up to 2-3 weeks Harsh penalties when caught Winner for legal safety: Peptides are in a clearer legal gray area, while SARMs face more regulatory scrutiny

doi: 10.1016/j.nbd.2017.04.004 182 RohatgiR.MilenkovicL.ScottM

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